1.Inhibition of lipofuscin and free
radical scavenging effect: mice by
intraperitoneal injection of pearl powder suspension 200mg / (our
hospital days)
× 25 days, allows cardiac and brain tissue of lipofuscin is significantly reduced in liver tissue.significantly affected. PFC and its separation from the triangle mussel pearl powder extract the product using the chemiluminescence method for the determination of the role of O radicals. The
results showed that both inhibition of light the
role of the PFC
after the purification of the monomer composition of the PCM-1 strong, can
inhibit the
reaction of free radicals.
2. Anti-tumor effect: mice by intraperitoneal injection PFC40mg / (our hospital days) × 9 days, subcutaneously inoculated with S180 sarcoma cells 8.0 × l05 cells / ml in mice was significantly inhibited (P <0.01), inhibition rate of 34.8% ; the same dose of the drug can inhibit the subcutaneous inoculated with Lewis lung homogenate was 5.0 × 10 / ml in mice, inhibition rate of 13.89%, but no significant difference. The same dose of drugs prolong the survival time of inoculation against P388 / lymphatic leukemia in mice up to 14.75% (P <0.05), while significantly reducing animal spleen weighing up to 24.12% (P <0.01). In vitro against P388 / J cells, two doses the group PFC50μg/ml and the 100μg/ml, the medication 72 hours killing rates were 25.0% and 24.8% (P <0.01).
3. Other roles: Pearl extract to isolated rabbit intestinal inhibition.
2. Anti-tumor effect: mice by intraperitoneal injection PFC40mg / (our hospital days) × 9 days, subcutaneously inoculated with S180 sarcoma cells 8.0 × l05 cells / ml in mice was significantly inhibited (P <0.01), inhibition rate of 34.8% ; the same dose of the drug can inhibit the subcutaneous inoculated with Lewis lung homogenate was 5.0 × 10 / ml in mice, inhibition rate of 13.89%, but no significant difference. The same dose of drugs prolong the survival time of inoculation against P388 / lymphatic leukemia in mice up to 14.75% (P <0.05), while significantly reducing animal spleen weighing up to 24.12% (P <0.01). In vitro against P388 / J cells, two doses the group PFC50μg/ml and the 100μg/ml, the medication 72 hours killing rates were 25.0% and 24.8% (P <0.01).
3. Other roles: Pearl extract to isolated rabbit intestinal inhibition.
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